Nov 01, 2017 the previous articles provided an introduction to the results and analysis interface. Nov 12, 2019 the main strength of the current study is that we performed a network meta analysis, in addition to a pairwise meta analysis, to investigate differential effects of different statins with or. For the purposes of this roundup, were going to focus on software that allows for modular type synthesis in a patchable environment, whether that be with traditional cable type patching or arrangement of blocks or modules. Even in its earliest versions, comprehensive metaanalysis was easy to use. Advanced and specialized metaanalysis topics bayesian methods in metaanalysis meta regression metaanalysis of. In addition to providing an overview, these papers provide a quantitative assessment of how well a treatment works or. Jul 30, 2019 previous studies have raised concerns about the analysis and meta analysis of crossover experiments and we were aware of several families of experiments that used crossover designs and meta analysis. The one in this toad cartoon, for example, is a cumulative metaanalysis. Interpretation of results of meta analysis on different types. Meta analysis is a statistical technique, or set of statistical techniques, for summarising the results of several studies into a single estimate.
Analyses determined the effect sizes for various parental involvement programs overall and subcategories of involvement. We checked more than 150 retrievable textbooks on research synthesis methodology cover to cover, six different software programs regularly used for meta analysis, and the entire content of two leading journals on research synthesis. In practice, most meta analyses are performed in general statistical packages or dedicated meta analysis programs. Second edition evidencebased medicine supported by sanofi. This page provides information and resources about how to conduct a meta analysis. Aug 12, 2017 appendix b provides a detailed overview of the features of the software for meta.
A meta analysis is the use of statistical methods to summarise the results of these studies. We conducted a frequentist network meta analysis with randomeffects models to estimate the aggregate reductions in cardiovascular events and revascularization for each type of antihypertension medication compared with placebo and with each other. A metaanalysis of three studies total 175 participants indicated no significant difference in reduction of fatigue between the two types of training pooled standard mean difference. People with these types of agendas may be more likely to abuse meta analysis due to personal bias. The amount and types of data you collect, as well as the number of collaborators who will be extracting it, will dictate which. Metaanalysis is a set of techniques used to combine the results of a number of different reports into one report to create a single, more precise estimate of an effect ferrer, 1998. The overall conclusions of a meta analysis, however, depend heavily on the quality of the meta analytic process, and an appropriate evaluation of the quality of meta analysis meta evaluation can be challenging. Such analyses are essentially observational, using trials as the unit of enrollment rather than individual patients. Analysis cma program was used to calculate the pooled mean effect. Although meta analysis software makes effect size calculations simple, it is good practice for researchers to understand what computations are being used. A metaanalysis of the efficacy of different types of parental involvement programs for urban students. Researchers often use a form or table to capture the data they will then summarize or analyze. Here, wed like to highlight 10 modularstyle software programs that are worth looking into.
Metaanalyses in which the outcome was allcause mortality displayed substantially lower betweenstudy heterogeneity than other metaanalyses. The target audience includes postgraduate students conducting a meta analysis or beginning researchers in meta analysis. In the current study, we conducted a meta analysis to more accurately evaluate the relationships between plce1 rs2274223, rs3765524, rs753724, rs11187842, and rs7922612 single nucleotide polymorphisms snps and risk for different types of cancer. Hoffman, in basic biostatistics for medical and biomedical practitioners second edition, 2019.
Charting the landscape of graphical displays for meta. The effects of different types of treatment for anxiety on. Psychotherapy for depression across different age groups. There are also different types of metaanalytic studies. Meta analysis is a set of techniques used to combine the results of a number of different reports to create a single, more precise estimate of an effect ferrer, 1998. Meta analysis of trials provides a precise estimate of treatment effect, giving due weight to the size of the different studies included. Only 1 network metaanalysis 9 has compared the effectiveness of different classes of antihypertension medications in preventing cardiovascular events, but this meta. In practice, this implies the combination of the results of several individual clinical trials using specialized statistical. Cma is quite expensive about 600 for academic use, but save your time when you need to convert data of different type, and the book by m. The analysis should include published and unpublished results to avoid publication bias.
We therefore considered it timely to provide a systematic overview of the features, criterion validity, and usability of the currently available software that is dedicated to metaanalysis of causal therapeutic and etiologic studies. Efficacy of different types of aerobic exercise in. A quality analyst by day and a dynamic blogger by night, ste is an out of thebox thinker whose thinking cap is never on the resting mode. Quality assessment may determine inclusionexclusion andor sensitivity analyses. Metaanalysis of trials provides a precise estimate of treatment effect, giving due weight to the size of the different studies included. There are more and more softwares for ma available, particularly in the field of medical research. When means and standard deviations were not reported, any other precise statistic accommodated by cma was used. Data extraction for complex metaanalysis decimal guide. The effects of different types of treatment for anxiety on repetitive negative thinking. We focus on those that are the most flexible and the most suited to the types of analyses carried out by ecologists and evolutionary biologists.
Whether you plan to perform a metaanalysis or not, you will need to establish a regimented approach to extracting data. Read 146 answers by scientists with 234 recommendations from their colleagues to the question asked by aref bin abdulhak on jan 16, 20. This module now proceeds towards the interpretation of results. How to run a metaanalysis and interpret the results. With meta analysis methods playing a crucial role in health research in recent years, this important and clearlywritten book provides a muchneeded survey of the field.
Previous studies have raised concerns about the analysis and metaanalysis of crossover experiments and we were aware of several families of experiments that used. Ratios of heterogeneity variances between different types of metaanalysis are presented in table 3. Metaanalysis is a statistical technique, or set of statistical techniques, for summarising the results of several studies into a single estimate. Comparing the impact of different exercise interventions on. Electronic search yielded 2194 records and the selection resulted. Meta analysis is a statistical procedure for analyzing the combined data from different studies, and can be a major source of concise uptodate information. We applied a multitiered search strategy to find the metaanalytic graphs proposed and introduced so far. To our knowledge, this is the first metaanalysis of psychotherapy trials for depression in all age groups and the largest metaanalysis of depression psychotherapies ever. The theory and statistical foundations of metaanalysis continually evolve. We checked more than 150 retrievable textbooks on research synthesis. Appendix b provides a detailed overview of the features of the software for meta. Dec, 2016 network meta analysis nma, multiple outcomes analysis and analysis combining different types of data are considered in a manner that can be useful across a range of data collection programmes.
A metaanalysis of the efficacy of different types of. Metaanalysis is the quantitative analysis of the results included in an sr. I have conducted several metaanalyses over the past several years, and comprehensive metaanalysis has been the main software i have relied on. The guide has been shown to be both easy to learn and useful in a small pilot study. Network metaanalysis nma, multiple outcomes analysis and analysis combining different types of data are considered in a manner that can be useful across a range of data. Software for statistical meta analysis 175 finally, there are standalone packages for meta analysis that come in many different flavors. A systematic comparison of software dedicated to meta. Common components like forest plot interpretation, software that may be used, special cases for meta analysis, such as subgroup. It is user friendly and it provides a wide range of options to fit the different types of effect size information found in different types of studies. We applied a multitiered search strategy to find the meta analytic graphs proposed and introduced so far. Different types of software testers the solitary writer. Interpretation of results of meta analysis on different types of plot. A clear difference between the various tools is whether they are stand.
Single nucleotide polymorphisms in plce1 for cancer risk of. The theory and statistical foundations of meta analysis continually evolve, providing solutions to many new and challenging problems. Software for statistical metaanalysis 175 finally, there are standalone packages for metaanalysis that come in many different flavors. The most severe fault in meta analysis often occurs when the person or persons doing the meta analysis have an economic, social, or political agenda such as the passage or defeat of legislation. Single nucleotide polymorphisms in plce1 for cancer risk of different types. A brief discussion of the different types of biases that may compromise the results of.
The move towards evidencebased health care and practice is. In practice, this implies the combination of the results of several individual clinical trials using specialized statistical methodology. Good meta analyses aim for complete coverage of all. This meta analysis of 51 studies examines the relationship between various kinds of parental involvement programs and the academic achievement of prekindergarten12thgrade school children. Single nucleotide polymorphisms in plce1 for cancer risk.
May 10, 2010 the efficacy and the optimal type and volume of aerobic exercise ae in fibromyalgia syndrome fms are not established. This publication type value is applied to articles that indicate the presence of a qualitative methodology that integrates results from a number of different, but interrelated studies. A bayesian network metaanalysis of 5 different fusion surgi. The purpose of this commentary is to expand on existing articles describing metaanalysis. Technique that statistically combines the results of quantitative studies to provide a more precise effect of the results. The aims of metaanalysis are to increase statistical power. Meta analysis is the quantitative analysis of the results included in an sr. How to run a meta analysis and interpret the results. Xiaoying li, 1, 2 xuelian li, 1, 2 min jiang, 1, 2 wen tian, 1, 2 and baosen zhou 1, 2, author. A metaanalysis of three studies total 175 participants indicated no significant difference in reduction of fatigue between the two types of training pooled standard mean. We therefore assessed the efficacy of different types and volumes of ae in fms. Meta analysis takes data from several different studies and produces a single estimate of the effect, usually of a treatment or risk factor. Health benefits of different sport disciplines for adults. This metaanalysis summarized the results of one casecontrol and eight cohort studies that investigated the associations between shift work and the risks of different types of.
The aim was to assess the quality and strength of evidence for the health benefits of specific sport disciplines. The validity of the metaanalysis depends on the quality. These softwares can be of interest for a meta analysis concerning the type of experimental data. Metaanalysis is increasingly used as a key source of evidence synthesis to inform clinical practice. Metaanalysis is a set of techniques used to combine the results of. To identify families of experiments that used meta analysis, to investigate their methods for effect size construction and aggregation, and to assess the reproducibility and validity of their. Whether you plan to perform a meta analysis or not, you will need to establish a regimented approach to extracting data.
Meta analysis provides a framework for combining the results of several clinical trials and drawing inferences about the effectiveness of medical treatments. We describe what meta analysis is, what heterogeneity is, and how it affects meta analysis, effect size, the modeling techniques of meta analysis, and strengths and weaknesses of meta analysis. Hoffman, in biostatistics for medical and biomedical practitioners, 2015. Researchers often use a form or table to capture the data they will. Could anyone suggest a free software for meta analysis. Interpretation of results of meta analysis on different. Metaanalysis is a statistical procedure for analyzing the combined data from different studies, and can be a major source of concise uptodate information. Effect of different types of statins on kidney function. A basic tutorial arindam basu university of canterbury may 12, 2017 concepts of metaanalyses meta analysis refers to a process of integration of the results. Comparing the impact of different exercise interventions. Analysis the effect size and precision of each individual study are aggregated into a summary statistic, which can be done with meta analysis software. Meta analysis is increasingly used as a key source of evidence synthesis to inform clinical practice. Effect of different types of statins on kidney function decline and proteinuria. Metaanalysis would be used for the following purposes.
Comparison of cardiovascular events among users of. Methods for metaanalysis in medical research wiley. Predicting the extent of heterogeneity in metaanalysis. Comparison of cardiovascular events among users of different. The meta analysis results involve basic summary statistics, forest plots and model statistics. A meta analysis pools together the populations from different studies, such as randomized controlled trials, into one statistical analysis and treats them as one large study population with one conclusion. I would be interested in the combined effect size of different kinds of data. More importantly, michael borenstein and his colleagues were readily available to assist with the few questions i. Metaanalysis for families of experiments in software. The efficacy and the optimal type and volume of aerobic exercise ae in fibromyalgia syndrome fms are not established.
1433 1047 1617 488 1288 423 269 447 1315 1168 121 1146 370 669 24 52 1065 1527 682 1210 1572 989 913 1384 1047 705 216 1190 1128 1123 553 1318 211 416 452 248 1024 1072 1348 340 1442